Detailed description page of Hmrbase2

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12412 details
Primary information
ID12412
Uniprot IDO19113
DescriptionCCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor)
OrganismSus scrofa
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Suina; Suidae (pigs); Sus; Sus scrofa (Pig)
Subcellular LocationSecreted; extracellular space; extracellular matrix
Developmental StageNA
SimilarityBelongs to the CCN family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionMajor connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts; myofibroblasts; endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Length349
Molecular Weight38
NameCCN family member 2
SequenceDCSGQCQCAAGKRRACPAGVSLVLDGCGCCRLCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA
Sequence map32-49
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA