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12385 details
Primary information
ID12385
Uniprot IDQ9R229
DescriptionBone morphogenetic protein 10 (BMP-10)
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted
Developmental StageDown-regulation after 14.5 dpc is critical for cardiomyocytes to undergo normal developmental hypertrophic growth in early postnatal life.
SimilarityBelongs to the TGF-beta family.
Tissue SpecificityIn the embryo; expressed exclusively in the ventricular trabecular myocardium of the developing heart from 9.0 dpc-13.5 dpc. By 16.5 dpc-18.5 dpc; only detectable in atria. Highly expressed in the adu
Post Translational ModificationNA
FunctionRequired for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1; BMPR1A/ALK3 and BMPR1B/ALK6; leading to activation of SMAD1; SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Length421
Molecular Weight47
NameBone morphogenetic protein 10
SequenceAKGNYCKKTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLDPISILYLDKGVVTYKFKYEGMAVSECGCR
Sequence map321-01
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA