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12368 details
Primary information
ID12368
Uniprot IDO54775
DescriptionCCN family member 4 (ELM-1) (WNT1-inducible-signaling pathway protein 1) (WISP-1)
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the CCN family.
Tissue SpecificityHighly expressed in kidney and lung. Lower levels in heart; brain; spleen; liver; skeletal muscle and testis. Expressed in low metastatic melanoma cells.
Post Translational ModificationNA
FunctionDownstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans; decorin and biglycan. Suppresses tumor growth in vivo.
Length367
Molecular Weight40
NameCCN family member 4
SequenceALSPTPTTMTFTPAPLEETTTRPEFCKWPCECPQSPPRCPLGVSLITDGCECCKICAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYTNGESFQPNCRYNCTCIDGTVGCTPLCLSPRPPRLWCRQPRHVRVPGQCCEQWVCDDDARRPRQTALLDTRAFAASGAVEQRYENCIAYTSPWSPCSTTCGLGISTRISNVNARCWPEQESRLCNLRPCDVDIQLHIKAGKKCLAVYQPEEATNFTLAGCVSTRTYRPKYCGVCTDNRCCIPYKSKTISVDFQCPEGPGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFEEIAN
Sequence map29-07
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA