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12362 details
Primary information
ID12362
Uniprot IDP55102
DescriptionInhibin beta A chain (Activin beta-A chain)
OrganismEquus caballus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Perissodactyla (odd-toed ungulates); Equidae (horses); Equus; Equus; Equus caballus (Horse)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the TGF-beta family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionInhibins and activins inhibit and activate; respectively; the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion; gonadal hormone secretion; germ cell development and maturation; erythroid differentiation; insulin secretion; nerve cell survival; embryonic axial development or bone growth; depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Length426
Molecular Weight47
NameInhibin beta A chain
SequenceLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINQYRLRGHNPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
Sequence map318-06
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA