Detailed description page of Hmrbase2

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12360 details
Primary information
ID12360
Uniprot IDP17490
DescriptionInhibin alpha chain
OrganismRattus norvegicus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the TGF-beta family.
Tissue SpecificityMainly expressed in ovary and testis. Alpha- and beta-B-subunits are the predominant forms found in testis. Also found in placenta; pituitary; adrenal gland; bone marrow; kidney; spinal chord and brai
Post Translational ModificationProteolytic processing yields a number of bioactive forms; consisting either solely of the mature alpha chain; of the most N-terminal propeptide linked through a disulfide bond to the mature alpha cha
FunctionInhibins and activins inhibit and activate; respectively; the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion; gonadal hormone secretion; germ cell development and maturation; erythroid differentiation; insulin secretion; nerve cell survival; embryonic axial development or bone growth; depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Length366
Molecular Weight39
NameInhibin alpha chain
SequenceAPSMPWPWSPAALRLLQRPPEEPSAHAFCHRAALNISFQELGWDRWIVHPPSFIFHYCHGSCGMPTSDLPLPVPGAPPTPAQPLFLVPGAKPCCAALPGSMRSLRVRTTSDGGYSFKYEMVPNLITQHCACI
Sequence map240-06
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA