| Primary information |
|---|
| ID | 12335 |
| Uniprot ID | P07355 |
| Description | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted; extracellular space; extracellular matrix; basement membrane |
| Developmental Stage | NA |
| Similarity | Belongs to the annexin family. |
| Tissue Specificity | NA |
| Post Translational Modification | Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. |
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation; probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 |
| Length | 339 |
| Molecular Weight | 38 |
| Name | Annexin A2 |
| Sequence | TVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD |
| Sequence map | 7-39 |
| PDB ID | 1W7B; 1XJL; 2HYU; 2HYV; 2HYW; 4DRW; 4FTG; 4HRH; 5LPU; 5LPX; 5LQ0; 5LQ2; 5N7D; 5N7F; 5N7G; 6TWQ; 6TWU |
| Drugpedia | DB11638;DB00591;DB06245;DB00031; |
| Receptor | NA |
| Domain | A pair of annexin repeats may form one binding sit |
| Pharmaceutical Use | NA
|