Detailed description page of Hmrbase2

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12325 details
Primary information
ID12325
Uniprot IDA1YL68
DescriptionAgouti-signaling protein (ASP) (Agouti switch protein)
OrganismMacaca nigra
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae (Old World monkeys); Cercopithecinae; Macaca (macaques); Macaca nigra (Celebes black macaque) (Crested black macaque)
Subcellular LocationSecreted
Developmental StageNA
SimilarityNA
Tissue SpecificityNA
Post Translational ModificationNA
FunctionInvolved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP; leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
Length132
Molecular Weight14
NameAgouti-signaling protein
SequencePPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKSPAPACCDPCASCQCRFFRSACSCRVLSLNC
Sequence map25-12
PDB IDNA
DrugpediaNA
ReceptorNA
DomainThe presence of a 'disulfide through disulfide kno
Pharmaceutical UseNA