Detailed description page of Hmrbase2

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12324 details
Primary information
ID12324
Uniprot IDQ865F0
DescriptionAgouti-signaling protein (ASP) (Agouti switch protein)
OrganismFelis catus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Feliformia; Felidae (cat family); Felinae; Felis; Felis catus (Cat) (Felis silvestris catus)
Subcellular LocationSecreted
Developmental StageNA
SimilarityNA
Tissue SpecificityNA
Post Translational ModificationNA
FunctionInvolved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP; leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
Length135
Molecular Weight14
NameAgouti-signaling protein
SequenceLAPEEKPRDDRNLRSNSSMNMLDLSSVSIVALNKKSKKISRKEAEKKRSSKKKASMKNVAQPRRPRPPPPAPCVATRDSCKPPAPACCDPCASCQCRFFRSSCSCRVLNPTC
Sequence map25-15
PDB IDNA
DrugpediaNA
ReceptorNA
DomainThe presence of a 'disulfide through disulfide kno
Pharmaceutical UseNA