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12301 details
Primary information
ID12301
Uniprot IDP79121
DescriptionMetalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3)
OrganismBos taurus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos (oxen; cattle); Bos taurus (Bovine)
Subcellular LocationSecreted; extracellular space; extracellular matrix.
Developmental StageNA
SimilarityBelongs to the protease inhibitor I35 (TIMP) family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionComplexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.
Length211
Molecular Weight24
NameMetalloproteinase inhibitor 3
SequenceTCSPSHPQDAFCNSDIVIRAKVVGKKLLKEGPFGTMVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMFSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
Sequence map27-31
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA