Detailed description page of Hmrbase2

This page displays user query in tabular form.

12299 details
Primary information
ID12299
Uniprot IDO00744
DescriptionProtein Wnt-10b (Protein Wnt-12)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted; extracellular space; extracellular matrix
Developmental StageInfant brain has higher levels of WNT10B than adult brain.
SimilarityBelongs to the Wnt family.
Tissue SpecificityDetected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.
Post Translational ModificationPalmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
FunctionMember of the Wnt ligand gene family that encodes for secreted proteins; which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness; pluripotency and cell fate decisions. Acts in the immune system; mammary gland; adipose tissue; bone and skin.
Length389
Molecular Weight43
NameProtein Wnt-10b
SequenceEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
Sequence map35-29
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA