| Primary information |
|---|
| ID | 12296 |
| Uniprot ID | P02766 |
| Description | Transthyretin (ATTR) (Prealbumin) (TBPA) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted Cytoplasm. |
| Developmental Stage | NA |
| Similarity | Belongs to the transthyretin family. |
| Tissue Specificity | Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. |
| Post Translational Modification | Not glycosylated under normal conditions. Following unfolding; caused for example by variant AMYL-TTR 'Gly-38'; the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex; le |
| Function | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. |
| Length | 147 |
| Molecular Weight | 15 |
| Name | Transthyretin |
| Sequence | PTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE |
| Sequence map | 23-27 |
| PDB ID | 1BM7; 1BMZ; 1BZ8; 1BZD; 1BZE; 1DVQ; 1DVS; 1DVT; 1DVU; 1DVX; 1DVY; 1DVZ; 1E3F; 1E4H; 1E5A; 1ETA; 1ETB |
| Drugpedia | DB07201;DB07176;DB07047;DB06935;DB02417;DB07694;DB |
| Receptor | NA |
| Domain | Each monomer has two 4-stranded beta sheets and th |
| Pharmaceutical Use | NA
|