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12296 details
Primary information
ID12296
Uniprot IDP02766
DescriptionTransthyretin (ATTR) (Prealbumin) (TBPA)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted Cytoplasm.
Developmental StageNA
SimilarityBelongs to the transthyretin family.
Tissue SpecificityDetected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Post Translational ModificationNot glycosylated under normal conditions. Following unfolding; caused for example by variant AMYL-TTR 'Gly-38'; the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex; le
FunctionThyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Length147
Molecular Weight15
NameTransthyretin
SequencePTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
Sequence map23-27
PDB ID1BM7; 1BMZ; 1BZ8; 1BZD; 1BZE; 1DVQ; 1DVS; 1DVT; 1DVU; 1DVX; 1DVY; 1DVZ; 1E3F; 1E4H; 1E5A; 1ETA; 1ETB
DrugpediaDB07201;DB07176;DB07047;DB06935;DB02417;DB07694;DB
ReceptorNA
DomainEach monomer has two 4-stranded beta sheets and th
Pharmaceutical UseNA