Detailed description page of Hmrbase2

This page displays user query in tabular form.

12288 details
Primary information
ID12288
Uniprot IDP09486
DescriptionSPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted acidic and rich in cysteine)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted; extracellular space; extracellular matrix; basement membrane
Developmental StageExpressed at high levels in tissues undergoing morphogenesis; remodeling and wound repair.
SimilarityBelongs to the SPARC family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionAppears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper; several types of collagen; albumin; thrombospondin; PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Length303
Molecular Weight34
NameSPARC
SequencePQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI
Sequence map23-03
PDB ID1BMO; 1NUB; 1SRA; 2V53;
DrugpediaDB11093;DB11348;DB14481;
ReceptorNA
DomainNA
Pharmaceutical UseNA