| Primary information |
|---|
| ID | 12284 |
| Uniprot ID | P0DUJ4 |
| Description | NU-theraphotoxin-Preg1a (N-TRTX-Preg1a) (NU-TRTX-Preg1a) |
| Organism | Poecilotheria regalis |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Chelicerata; Arachnida; Araneae (spiders); Mygalomorphae (mygalomorph spiders); Theraphosidae (tarantulas); Poecilotheria; Poecilotheria regalis (Indian ornamental tree spider) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Expressed by the venom gland. |
| Post Translational Modification | NA |
| Function | Toxin that acts as an agonist on melanocortin receptors (MC1R; MC3R; MC5R; MC5R). After binding to MC1R; the peptide activates the hMC1R/Gs pathway; but after binding to MC4R; it is not able to activate or antagonize the MC4R/Gs pathway. Inhibits melanocyte stimulating hormone (MSH)-binding to human receptors (Ki=1.8 uM to MC1R; Ki=19.8 uM to MC3R; Ki=7.1 uM to MC4R; Ki=10.0 uM to MC5R). This toxin is structurally unrelated to the natural agonists. |
| Length | 28 |
| Molecular Weight | 2 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | 6SAA; |
| Drugpedia | NA |
| Receptor | NA |
| Domain | The presence of a 'disulfide through disulfide kno |
| Pharmaceutical Use | NA
|