Detailed description page of Hmrbase2

This page displays user query in tabular form.

12280 details
Primary information
ID12280
Uniprot IDP35625
DescriptionMetalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted; extracellular space; extracellular matrix.
Developmental StageNA
SimilarityBelongs to the protease inhibitor I35 (TIMP) family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionComplexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1; MMP-2; MMP-3; MMP-7; MMP-9; MMP-13; MMP-14 and MMP-15.
Length211
Molecular Weight24
NameMetalloproteinase inhibitor 3
SequenceTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
Sequence map27-31
PDB ID3CKI;
DrugpediaDB05383;
ReceptorNA
DomainNA
Pharmaceutical UseNA