Primary information |
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ID | 12276 |
Uniprot ID | P0DL36 |
Description | Mu-scoloptoxin(03)-Ssm2a (Mu-SLPTX(03)-Ssm2a) (Mu-scoloptoxin-Ssm6a) (Mu-SLPTX-Ssm6a) |
Organism | Scolopendra subspinipes |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Myriapoda; Chilopoda (centipedes); Pleurostigmophora; Epimorpha; Scolopendromorpha; Scolopendridae; Scolopendra; Scolopendra subspinipes (Vietnamese centipede) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the scoloptoxin-03 family. |
Tissue Specificity | Expressed by the venom gland. |
Post Translational Modification | NA |
Function | Gating-modifier toxin that inhibits voltage-gated sodium channel with a preference for hNav1.7/SCN9A (IC(50)=25.4 nM) over hNav1.1/SCN1A (IC(50)=4.1 uM); hNav1.2/SCN2A (IC(50)=813 nM); and hNav1.6/SCN8A (IC(50)=15.2 uM) |
Length | 112 |
Molecular Weight | 12 |
Name | NA |
Sequence | NA |
Sequence map | NA |
PDB ID | 2MUN; 2MZ4; |
Drugpedia | NA |
Receptor | NA |
Domain | Is exclusively composed of 4 tightly packed alpha |
Pharmaceutical Use | NA
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