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12276 details
Primary information
ID12276
Uniprot IDP0DL36
DescriptionMu-scoloptoxin(03)-Ssm2a (Mu-SLPTX(03)-Ssm2a) (Mu-scoloptoxin-Ssm6a) (Mu-SLPTX-Ssm6a)
OrganismScolopendra subspinipes
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Myriapoda; Chilopoda (centipedes); Pleurostigmophora; Epimorpha; Scolopendromorpha; Scolopendridae; Scolopendra; Scolopendra subspinipes (Vietnamese centipede)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the scoloptoxin-03 family.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationNA
FunctionGating-modifier toxin that inhibits voltage-gated sodium channel with a preference for hNav1.7/SCN9A (IC(50)=25.4 nM) over hNav1.1/SCN1A (IC(50)=4.1 uM); hNav1.2/SCN2A (IC(50)=813 nM); and hNav1.6/SCN8A (IC(50)=15.2 uM)
Length112
Molecular Weight12
NameNA
SequenceNA
Sequence mapNA
PDB ID2MUN; 2MZ4;
DrugpediaNA
ReceptorNA
DomainIs exclusively composed of 4 tightly packed alpha
Pharmaceutical UseNA