| Primary information |
|---|
| ID | 12271 |
| Uniprot ID | P0DUS3 |
| Description | Z-limacoditoxin(1)-Dv4 (Z-LCTX(1)-Dv4) (Vulnericin) |
| Organism | Doratifera vulnerans |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota (winged insects); Neoptera; Endopterygota; Amphiesmenoptera; Lepidoptera (butterflies and moths); Glossata; Neolepidoptera; Heteroneura; Ditrysia; Apoditrysia; Zygaenoidea; Limacodidae (slug caterpillar moths); Doratifera; Doratifera vulnerans (Mottled cup moth) |
| Subcellular Location | Secreted |
| Developmental Stage | Only secreted by caterpillars. Adult moth do not have spines. |
| Similarity | Belongs to the limacoditoxin-1 (ACP-like) family. |
| Tissue Specificity | Expressed by the spine venom secretory cell. The spine is a cuticular structure containing at its base a single large nucleated venom secretory cell; as well as a central venom reservoir extending thr |
| Post Translational Modification | NA |
| Function | Potently activates insect GPCR. More precisely; it activates the ACP receptor (ACPR) from the mosquito A.aegypti (EC(50)=3.07 nM) with a potency comparable to that of the endogenous ligand. Has no activity on receptors of the closely related neuropeptides adipokinetic hormone and corazonin. In vivo; does not reveal any observable effects when injected into crickets (A.domesticus). Does not induce increase in intracellular calcium in mouse DRG neurons; suggesting that it does not induce pain. |
| Length | 35 |
| Molecular Weight | 4 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
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