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12245 details
Primary information
ID12245
Uniprot IDP05543
DescriptionThyroxine-binding globulin (Serpin A7) (T4-binding globulin)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the serpin family.
Tissue SpecificityExpressed by the liver and secreted in plasma.
Post Translational ModificationNA
FunctionMajor thyroid hormone transport protein in serum.
Length415
Molecular Weight46
NameThyroxine-binding globulin
SequenceSPEGKVTACHSSQPNATLYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAAVPEVELSDQPENTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNPTEA
Sequence map27-55
PDB ID2CEO; 2RIV; 2RIW; 2XN3; 2XN5; 2XN6; 2XN7; 4X30; 4YIA;
DrugpediaDB01629;DB11100;DB08886;DB00023;DB00636;DB00286;DB
ReceptorNA
DomainNA
Pharmaceutical UseNA