| Primary information |
|---|
| ID | 12234 |
| Uniprot ID | A0A1L2F565 |
| Description | Parathyroid hormone 4 |
| Organism | Danio rerio |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes (carps and others); Cyprinoidei; Danionidae; Danioninae; Danio; Danio rerio (Zebrafish) (Brachydanio rerio) |
| Subcellular Location | Secreted |
| Developmental Stage | Detected at 0-3 hours post-fertilization (hpf); probably due to inheritance of maternal transcripts. Expression then declines; and increases again from 12 hpf onwards. Detected in the developing hypot |
| Similarity | Belongs to the parathyroid hormone family. |
| Tissue Specificity | Specifically expressed in a bilateral cluster of neurons in the dorsal region of the periventricular hypothalamus. Their axons project through the midbrain and hindbrain and down the spinal cord. |
| Post Translational Modification | NA |
| Function | Neuroendocrine peptide which is produced by a subset of neurons in the hypothalamus. Activates the G-protein coupled receptors pth1ra; pth1rb and pth2r with similar affinity. Receptor binding stimulates intracellular cAMP production. Plays a role in bone mineralization by regulating expression of factors involved in phosphate homeostasis. Important for embryonic bone development. |
| Length | 121 |
| Molecular Weight | 13 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|