Primary information |
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ID | 12234 |
Uniprot ID | A0A1L2F565 |
Description | Parathyroid hormone 4 |
Organism | Danio rerio |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes (carps and others); Cyprinoidei; Danionidae; Danioninae; Danio; Danio rerio (Zebrafish) (Brachydanio rerio) |
Subcellular Location | Secreted |
Developmental Stage | Detected at 0-3 hours post-fertilization (hpf); probably due to inheritance of maternal transcripts. Expression then declines; and increases again from 12 hpf onwards. Detected in the developing hypot |
Similarity | Belongs to the parathyroid hormone family. |
Tissue Specificity | Specifically expressed in a bilateral cluster of neurons in the dorsal region of the periventricular hypothalamus. Their axons project through the midbrain and hindbrain and down the spinal cord. |
Post Translational Modification | NA |
Function | Neuroendocrine peptide which is produced by a subset of neurons in the hypothalamus. Activates the G-protein coupled receptors pth1ra; pth1rb and pth2r with similar affinity. Receptor binding stimulates intracellular cAMP production. Plays a role in bone mineralization by regulating expression of factors involved in phosphate homeostasis. Important for embryonic bone development. |
Length | 121 |
Molecular Weight | 13 |
Name | NA |
Sequence | NA |
Sequence map | NA |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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