Detailed description page of Hmrbase2

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12234 details
Primary information
ID12234
Uniprot IDA0A1L2F565
DescriptionParathyroid hormone 4
OrganismDanio rerio
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes (carps and others); Cyprinoidei; Danionidae; Danioninae; Danio; Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular LocationSecreted
Developmental StageDetected at 0-3 hours post-fertilization (hpf); probably due to inheritance of maternal transcripts. Expression then declines; and increases again from 12 hpf onwards. Detected in the developing hypot
SimilarityBelongs to the parathyroid hormone family.
Tissue SpecificitySpecifically expressed in a bilateral cluster of neurons in the dorsal region of the periventricular hypothalamus. Their axons project through the midbrain and hindbrain and down the spinal cord.
Post Translational ModificationNA
FunctionNeuroendocrine peptide which is produced by a subset of neurons in the hypothalamus. Activates the G-protein coupled receptors pth1ra; pth1rb and pth2r with similar affinity. Receptor binding stimulates intracellular cAMP production. Plays a role in bone mineralization by regulating expression of factors involved in phosphate homeostasis. Important for embryonic bone development.
Length121
Molecular Weight13
NameNA
SequenceNA
Sequence mapNA
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA