Detailed description page of Hmrbase2

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12213 details
Primary information
ID12213
Uniprot IDQ99P68
DescriptionSclerostin
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted; extracellular space; extracellular matrix
Developmental StageNA
SimilarityBelongs to the sclerostin family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionNegative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Length211
Molecular Weight23
NameSclerostin
SequenceGWQAFRNDATEVIPGLGEYPEPPPENNQTMNRAENGGRPPHHPYDAKDVSEYSCRELHYTRFLTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRVKWWRPNGPDFRCIPDRYRAQRVQLLCPGGAAPRSRKVRLVASCKCKRLTRFHNQSELKDFGPETARPQKGRKPRPGARGAKANQAELENAY
Sequence map27-31
PDB ID2KD3;
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA