Detailed description page of Hmrbase2

This page displays user query in tabular form.

12206 details
Primary information
ID12206
Uniprot IDB7ZS96
DescriptionTransthyretin (xTTR) (Prealbumin)
OrganismXenopus laevis
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus; Xenopus laevis (African clawed frog)
Subcellular LocationSecreted
Developmental StageExpressed in tadpoles from premetamorphic stage 53 until the end of prometamorphic stage 60. Expression levels reach a maximum at prometamorphic stages 58 to 59; then decline gradually during metamorp
SimilarityBelongs to the transthyretin family.
Tissue SpecificityDetected in plasma (at protein level). Expressed during metamorphosis in tadpole liver; but not in tadpole brain nor adult liver. Between 1.5 and 3 days of development; also expressed in the mesoderm
Post Translational ModificationNA
FunctionThyroid hormone-binding protein; with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4). Probably transports triiodothyronine from the bloodstream to the brain.
Length153
Molecular Weight16
NameTransthyretin
SequencePPGHASHGEADSKCPLMVKVLDAVRGIPAANLLVNVFRQTESGKWEQITSGKTTELGEIHNLTTDEQFTEGVYKIEFATKAFWGKLGLSPFHEYVDVVFTANDAGHRHYTIAVLLTPYSFSSTAIVSEPHDDL
Sequence map22-33
PDB IDNA
DrugpediaNA
ReceptorNA
DomainThe N-terminus strongly influences thyroid hormone
Pharmaceutical UseNA