Detailed description page of Hmrbase2

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12200 details
Primary information
ID12200
Uniprot IDQ99727
DescriptionMetalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the protease inhibitor I35 (TIMP) family.
Tissue SpecificityAbundant in heart and present at low levels in many other tissues.
Post Translational ModificationNA
FunctionComplexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1; MMP-2; MMP-3; MMP-7 and MMP-9.
Length224
Molecular Weight25
NameMetalloproteinase inhibitor 4
SequenceSCAPAHPQQHICHSALVIRAKISSEKVVPASADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQVLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTDWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
Sequence map33-44
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA