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12199 details
Primary information
ID12199
Uniprot IDP16975
DescriptionSPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted acidic and rich in cysteine)
OrganismRattus norvegicus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat)
Subcellular LocationSecreted; extracellular space; extracellular matrix; basement membrane
Developmental StageNA
SimilarityBelongs to the SPARC family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionAppears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper; several types of collagen; albumin; thrombospondin; PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Length301
Molecular Weight34
NameSPARC
SequencePQTEAAEEMVAEETVVEETGLPVGANPVQVEMGEFEEGAEETVEEVVAENPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIAPCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALEEWAGCFGIKEQDINKDLVI
Sequence map23-01
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA