Detailed description page of Hmrbase2

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12196 details
Primary information
ID12196
Uniprot IDQ16623
DescriptionSyntaxin-1A (Neuron-specific antigen HPC-1)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationCytoplasmic vesicle; secretory vesicle; synaptic vesicle membrane
Developmental StageNA
SimilarityBelongs to the syntaxin family.
Tissue SpecificityIsoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart; liver; fat; skeletal muscle; kidney and brain.
Post Translational ModificationPhosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1.
FunctionPlays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis
Length288
Molecular Weight33
NameSyntaxin-1A
SequenceKDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIVIASTVGGIFA
Sequence map5-48
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA