| Primary information |
|---|
| ID | 11967 |
| Uniprot ID | Q9VET0 |
| Description | Neuropeptide F (NPF) (dNPF) |
| Organism | Drosophila melanogaster |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota (winged insects); Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae (pomace flies); Drosophilinae; Drosophilini; Drosophila (fruit flies); Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster (Fruit fly) |
| Subcellular Location | Secreted |
| Developmental Stage | Expression is high in larvae seeking food and is down-regulated in late embryos coinciding with the onset of the behavior of older larvae; including food aversion; hypermobility; and cooperative burro |
| Similarity | Belongs to the NPY family. |
| Tissue Specificity | Expressed in midgut; brain lobes and ventral nerve cord of larvae. Predominantly expressed in two pairs of protocerebral neurons in the larval CNS (at protein level). Intense expression is also seen i |
| Post Translational Modification | NA |
| Function | Integral part of the sensory system that mediates food signaling; providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding; flight; and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation. NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults; rather than a general response to intoxication by sedative agents. Activation and inhibition of the NPF system reduces and enhances ethanol preference; respectively. Sexual experience; the NP |
| Length | 102 |
| Molecular Weight | 11 |
| Name | Neuropeptide F (NPF) (dNPF) |
| Sequence | NDVNTMADAYKFLQDLDTYYGDRARVRF |
| Sequence map | 28 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q9VNM1 |
| Domain | NA |
| Pharmaceutical Use | NA
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