Detailed description page of Hmrbase2

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11930 details
Primary information
ID11930
Uniprot IDQ810H5
DescriptionGalanin-like peptide
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the galanin family.
Tissue SpecificityIsoform 2 is found in brain; thymus and skin. Isoform 2 is found in the skin; in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels; isoform 2 is ex
Post Translational ModificationNA
Function[Isoform 1]- Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1; GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes; including the regulation of gonadotropin-releasing hormone secretion.; [Isoform 2]- Exhibits antimicrobial activity against Gram-negative bacterias; inducing bacterial membrane blebbing. Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature; a physiologic effects which does not appear to be mediated via GALR1 or GALR2.
Length117
Molecular Weight12
NameGalanin-like peptide
SequenceAPAHRGRGGWTLNSAGYLLGPVLPVSSKADQGRKRDSALEILDLWKIIDGLPYSHSPRMT
Sequence map60
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA