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11917 details
Primary information
ID11917
Uniprot IDQ9UBC7
DescriptionGalanin-like peptide
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the galanin family.
Tissue SpecificityIsoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma; as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is fou
Post Translational ModificationNA
Function[Isoform 1]- Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1; GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes; including the regulation of gonadotropin-releasing hormone secretion.; [Isoform 2]- Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature; a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias; inducing bacterial membrane blebbing
Length116
Molecular Weight12
NameGalanin-like peptide
SequenceAPAHRGRGGWTLNSAGYLLGPVLHLPQMGDQDGKRETALEILDLWKAIDGLPYSHPPQPS
Sequence map60
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA