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11899 details
Primary information
ID11899
Uniprot IDQ8MJ80
DescriptionHepcidin
OrganismSus scrofa
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Suina; Suidae (pigs); Sus; Sus scrofa (Pig)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the hepcidin family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionLiver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1; leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma- absorption of dietary iron in the intestine; recycling of iron by macrophages; which phagocytose old erythrocytes and other cells; and mobilization of stored iron from hepatocytes.
Length82
Molecular Weight8
NameHepcidin
SequenceDTHFPICIFCCGCCRKAICGMCCKT
Sequence map25
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA