Detailed description page of Hmrbase2

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11878 details
Primary information
ID11878
Uniprot IDQ7T273
DescriptionHepcidin-2
OrganismDanio rerio
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes (carps and others); Cyprinoidei; Danionidae; Danioninae; Danio; Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the hepcidin family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionSeems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.
Length91
Molecular Weight10
NameHepcidin-2
SequenceQSHLSLCRFCCKCCRNKGCGYCCKF
Sequence map25
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA