| Primary information |
|---|
| ID | 11874 |
| Uniprot ID | Q5NVR8 |
| Description | Hepcidin |
| Organism | Pongo abelii |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Ponginae; Pongo; Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the hepcidin family. |
| Tissue Specificity | NA |
| Post Translational Modification | NA |
| Function | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1; leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma- absorption of dietary iron in the intestine; recycling of iron by macrophages; which phagocytose old erythrocytes and other cells; and mobilization of stored iron from hepatocytes. |
| Length | 84 |
| Molecular Weight | 9 |
| Name | Hepcidin |
| Sequence | DTHFPIYIFCCGCCHRSKCGMCCKT |
| Sequence map | 25 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|