| Primary information |
|---|
| ID | 11873 |
| Uniprot ID | Q9EQ21 |
| Description | Hepcidin |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the hepcidin family. |
| Tissue Specificity | Highly expressed in the liver and to a much lesser extent in the heart. Secreted in blood (PubMed-15124018). |
| Post Translational Modification | NA |
| Function | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin; leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma- absorption of dietary iron in the intestine; recycling of iron by macrophages; which phagocytose old erythrocytes and other cells; and mobilization of stored iron from hepatocytes. |
| Length | 83 |
| Molecular Weight | 9 |
| Name | Hepcidin |
| Sequence | DTNFPICIFCCKCCNNSQCGICCKT |
| Sequence map | 25 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|