Detailed description page of Hmrbase2

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11848 details
Primary information
ID11848
Uniprot IDQ5U9D2
DescriptionHepcidin
OrganismCanis lupus familiaris
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Caniformia; Canidae (dog; coyote; wolf; fox); Canis; Canis lupus (Gray wolf); Canis lupus familiaris (Dog) (Canis familiaris)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the hepcidin family.
Tissue SpecificityNA
Post Translational ModificationNA
FunctionLiver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1; leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma- absorption of dietary iron in the intestine; recycling of iron by macrophages; which phagocytose old erythrocytes and other cells; and mobilization of stored iron from hepatocytes.
Length85
Molecular Weight9
NameHepcidin
SequenceDTHFPICIFCCGCCKTPKCGLCCKT
Sequence map25
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA