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11841 details
Primary information
ID11841
Uniprot IDQ9H1Z8
DescriptionAugurin (Esophageal cancer-related gene 4 protein) (ECRG4)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the augurin family.
Tissue SpecificityExpressed in the brain; with expression in the epithelial cell layer of the choroid plexus (at protein level).
Post Translational ModificationNA
FunctionProbable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system. ECRG4-induced senescence is characterized by G1 arrest; RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.
Length148
Molecular Weight17
NameAugurin (Esophageal cancer-related gene 4 protein) (ECRG4)
SequenceQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDITYWLNRDRNGHEYYGDYYQRHYDEDSAIGPR
Sequence map62
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA