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11835 details
Primary information
ID11835
Uniprot IDP20394
DescriptionExendin-3 (Glucagon-like 3)
OrganismHeloderma horridum horridum
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria (diapsids); Lepidosauria (lepidosaurs); Squamata (squamates); Bifurcata (split-tongued squamates); Unidentata; Episquamata; Toxicofera; Anguimorpha (anguimorph lizards); Neoanguimorpha (New World anguimorph lizards); Helodermatidae (beaded lizards); Heloderma;
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the glucagon family.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationNA
FunctionStimulates vasoactive intestinal peptide (VIP) receptors in high concentrations (100 nM); resulting in both an increase in cAMP and amylase secretion from pancreatic acini; although at low concentrations (between 0.3 and 3 nM) it increases cAMP without stimulating amylase release. Stimulates the GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
Length87
Molecular Weight9
NameExendin-3 (Glucagon-like 3)
SequenceHSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Sequence map39
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA