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11759 details
Primary information
ID11759
Uniprot IDP16501
DescriptionInsulin-like growth factor I-A (IGF-I') (IGF-IA) (xIGF-1) (Somatomedin)
OrganismXenopus laevis
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus; Xenopus laevis (African clawed frog)
Subcellular LocationSecreted
Developmental StageExpressed both maternally and zygotically after the midblastula transition. Present both dorsally and ventrally at the beginning of neurulation. Expression is restricted to the developing heart at the
SimilarityBelongs to the insulin family.
Tissue SpecificityExpressed in adult liver; lung; heart; kidney and peritoneal fat.
Post Translational ModificationNA
FunctionThe insulin-like growth factors; isolated from plasma; are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes head development by inhibiting Wnt signaling during embryogenesis
Length153
Molecular Weight17
NameInsulin-like growth factor I-A (IGF-I') (IGF-IA) (xIGF-1) (Somatomedin)
SequenceGPETLCGAELVDTLQFVCGDRGFYFSKPTGYGSNNRRSHHRGIVDECCFQSCDFRRLEMYCAPAKQAKSA
Sequence map70
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA