| Primary information |
|---|
| ID | 11745 |
| Uniprot ID | P21786 |
| Description | Allatotropin (AT) |
| Organism | Manduca sexta |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota (winged insects); Neoptera; Endopterygota; Amphiesmenoptera; Lepidoptera (butterflies and moths); Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Bombycoidea (hawk-moths); Sphingidae (hawkmoths); Sphinginae (small-eyed sphinx moth); Sphingini; Manduca; Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) |
| Subcellular Location | Secreted |
| Developmental Stage | Detected in the day 2 fifth-instar larva; wandering larva; pupa and adult. |
| Similarity | NA |
| Tissue Specificity | Expressed extensively in the brain; frontal ganglion and terminal ganglion of the day 2 fifth instar larva (at protein level). Not expressed in the larval brain after day 4 of the fifth instar; or in |
| Post Translational Modification | NA |
| Function | Neuropeptide stimulator of juvenile hormone synthesis. Cardioregulatory neurohormone that increases heart beat rate in the adult but not in the larva. Inhibits active ion transport in the midgut of feeding fourth instar and day 2 fifth instar larva; but not in the midgut of pharate or wandering fifth instar larva. |
| Length | 204 |
| Molecular Weight | 23 |
| Name | Allatotropin (AT) |
| Sequence | GFKNVEMMTARGF |
| Sequence map | 13 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
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