| Primary information |
|---|
| ID | 11696 |
| Uniprot ID | P0DMD6 |
| Description | Natriuretic peptide TsNP |
| Organism | Tityus serrulatus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Tityus; Tityus serrulatus (Brazilian scorpion) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the natriuretic peptide family. |
| Tissue Specificity | Expressed by the venom gland. |
| Post Translational Modification | NA |
| Function | Scorpion venom natriuretic peptide that increases the perfusion pressure; glomerular filtration rate and urinary flow in the isolated perfused rat kidney assay. Induces a decrease of the percentages of renal transport for sodium; potassium and chloride and an increase of the urinary cGMP concentration. Also down-regulates the mRNA expression of natriuretic peptide receptor-A (NPR1) in the kidneys whereas it up-regulates those of NPR-B (NPR2); NPR-C (NPR3) and guanylyl cyclase C (GUCY2C) mRNAs. May exhibit hypotensive and vasodepressor activities. |
| Length | 21 |
| Molecular Weight | 2 |
| Name | Natriuretic peptide TsNP |
| Sequence | KLSGCFGFKLDRIGTMSGLGC |
| Sequence map | 21 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|