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11696 details
Primary information
ID11696
Uniprot IDP0DMD6
DescriptionNatriuretic peptide TsNP
OrganismTityus serrulatus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Tityus; Tityus serrulatus (Brazilian scorpion)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the natriuretic peptide family.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationNA
FunctionScorpion venom natriuretic peptide that increases the perfusion pressure; glomerular filtration rate and urinary flow in the isolated perfused rat kidney assay. Induces a decrease of the percentages of renal transport for sodium; potassium and chloride and an increase of the urinary cGMP concentration. Also down-regulates the mRNA expression of natriuretic peptide receptor-A (NPR1) in the kidneys whereas it up-regulates those of NPR-B (NPR2); NPR-C (NPR3) and guanylyl cyclase C (GUCY2C) mRNAs. May exhibit hypotensive and vasodepressor activities.
Length21
Molecular Weight2
NameNatriuretic peptide TsNP
SequenceKLSGCFGFKLDRIGTMSGLGC
Sequence map21
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA