Primary information |
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ID | 11696 |
Uniprot ID | P0DMD6 |
Description | Natriuretic peptide TsNP |
Organism | Tityus serrulatus |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Tityus; Tityus serrulatus (Brazilian scorpion) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the natriuretic peptide family. |
Tissue Specificity | Expressed by the venom gland. |
Post Translational Modification | NA |
Function | Scorpion venom natriuretic peptide that increases the perfusion pressure; glomerular filtration rate and urinary flow in the isolated perfused rat kidney assay. Induces a decrease of the percentages of renal transport for sodium; potassium and chloride and an increase of the urinary cGMP concentration. Also down-regulates the mRNA expression of natriuretic peptide receptor-A (NPR1) in the kidneys whereas it up-regulates those of NPR-B (NPR2); NPR-C (NPR3) and guanylyl cyclase C (GUCY2C) mRNAs. May exhibit hypotensive and vasodepressor activities. |
Length | 21 |
Molecular Weight | 2 |
Name | Natriuretic peptide TsNP |
Sequence | KLSGCFGFKLDRIGTMSGLGC |
Sequence map | 21 |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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