| Primary information |
|---|
| ID | 11628 |
| Uniprot ID | P81615 |
| Description | Urocortin |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
| Subcellular Location | Secreted |
| Developmental Stage | In skin; levels decrease gradually from the telogen (resting) phase of the hair follicle with lowest levels observed in late anagen IV phase of active growth (at protein level). |
| Similarity | Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. |
| Tissue Specificity | In the organ of Corti; detected in the inner hair cell region (at protein level) (PubMed-12091910). Expressed in skin (at protein level) (PubMed-10690896). |
| Post Translational Modification | NA |
| Function | Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1; 2-alpha; and 2-beta. Plays a role in the establishment of normal hearing thresholds |
| Length | 122 |
| Molecular Weight | 13 |
| Name | Urocortin |
| Sequence | DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV |
| Sequence map | 40 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|