| Primary information |
|---|
| ID | 11512 |
| Uniprot ID | Q9EQX0 |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Cleaved into- - Ghrelin; Obestatin]. |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular Location | Secreted |
| Developmental Stage | Levels of n-octanoylated and n-decanoylated ghrelin drop by one third and 3-fold; respectively; between postnatal weeks 3 and 4 due to change of diet during weaning. |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | Mainly expressed in the gastrointestinal tract with higher levels in the stomach; medium levels in the duodenum; jejunum; ileum and colon. Low expression in the testis and brain. Not detected in the s |
| Post Translational Modification | O-n-octanoylation is essential for ghrelin activity. The O-n-decanoylated form ghrelin-C10 differs in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. Amidation of Leu-98 is |
| Function | Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect; induces adiposity and stimulates gastric acid secretion. Involved in growth regulation |
| Length | 117 |
| Molecular Weight | 13207 |
| Name | Ghrelin |
| Sequence | GSSFLSPEHQKAQQRKESKKPPAKLQPR |
| Sequence map | 28 (24-51) |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q99P50 |
| Domain | NA |
| Pharmaceutical Use | NA
|