| Primary information |
|---|
| ID | 11482 |
| Uniprot ID | P56942 |
| Description | Pro-MCH precursor [Cleaved into- - Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular Location | Secreted |
| Developmental Stage | Expression is enhanced between postnatal days 10 and 15. |
| Similarity | Belongs to the MCH family. |
| Tissue Specificity | Predominantly expressed in hypothalamus. Also found in heart; intestine; spleen and testis (spermatogonia; early spermatocytes and Sertoli cells). In brain only mature MCH and NEI peptides are present |
| Post Translational Modification | Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide; NGE; may also be produced. Preferential processing in neurons by pr |
| Function | NA |
| Length | 166 |
| Molecular Weight | 18645 |
| Name | Neuropeptide-glutamic acid-isoleucine |
| Sequence | EIGDEENSAKFPI |
| Sequence map | 13 (132-144) |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q8K3M8;Q3UY93 |
| Domain | NA |
| Pharmaceutical Use | NA
|