| Primary information |
|---|
| ID | 11423 |
| Uniprot ID | P20382 |
| Description | Pro-MCH precursor [Cleaved into- - Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the melanin-concentrating hormone family. |
| Tissue Specificity | Predominantly expressed in lateral hypothalamus; also detected in pallidum; neocortex and cerebellum. Also found in thymus; brown adipose tissue; duodenum and testis (spermatogonia; early spermatocyte |
| Post Translational Modification | Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide; NGE; may also be produced. Preferential processing in neurons by prohormone co |
| Function | NA |
| Length | 165 |
| Molecular Weight | 18723 |
| Name | Neuropeptide-glutamic acid-isoleucine |
| Sequence | EIGDEENSAKFPI |
| Sequence map | 13 (131-143) |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q99705; Q969V1;Q99705;Q969V1 |
| Domain | NA |
| Pharmaceutical Use | NA
|