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11417 details
Primary information
ID11417
Uniprot IDP19402
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Cleaved into- - NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-
OrganismCavia porcellus
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular LocationNA
Developmental StageNA
SimilarityBelongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post Translational ModificationSpecific enzymatic cleavages at paired basic residues yield the different active peptides.
FunctionACTH stimulates the adrenal glands to release cortisol
Length256
Molecular Weight28264
NameCorticotropin
SequenceSYSMEHFRWGKPVGKKRRPVKVYANGAEEESAEAFPLEF
Sequence map39 (125-163)
PDB IDNA
DrugpediaNA
ReceptorQ9Z1S9
DomainNA
Pharmaceutical UseNA