| Primary information |
|---|
| ID | 11410 |
| Uniprot ID | P14200 |
| Description | Pro-MCH precursor [Cleaved into- - Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular Location | Secreted |
| Developmental Stage | Expression is strongly increased in hypothalamus between postnatal days 12 and 20; to reach high constant values in adult. |
| Similarity | Belongs to the melanin-concentrating hormone family. |
| Tissue Specificity | MCH is present in all regions of the brain and in neurointermediate lobe of the pituarity gland; with highest concentrations in the hypothalamus. Also expressed to a much lesser extent in stomach; lam |
| Post Translational Modification | Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide; NGE; may also be produced. Preferential processing in neurons by pr |
| Function | MCH inhibits ACTH secretion at the end of the light on period which corresponds to the peak of the circadian rhythm in ACTH. Inhibits also stress induced ACTH release during the light off period of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array of neuronal functions. Stimulates sexual behavior when injected into the ventromedial nucleus; this effect is antagonized by NEI. In the medial preoptic area; stimulates anxiety and sexual behavior. Antagonizes inhibitory effect of melanotropin alpha on exploration behavior |
| Length | 165 |
| Molecular Weight | 18482 |
| Name | Melanin-concentrating hormone |
| Sequence | DFDMLRCMLGRVYRPCWQV |
| Sequence map | 19 (147-165) |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P97639 |
| Domain | NA |
| Pharmaceutical Use | NA
|