Detailed description page of Hmrbase2

This page displays user query in tabular form.

11105 details
Primary information
ID11105
Uniprot IDP01273
DescriptionGlucagon precursor [Cleaved into- - Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
OrganismMesocricetus auratus
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Cricetidae; Cricetinae; Mesocricetus.
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the glucagon family.
Tissue SpecificityNA
Post Translational ModificationProglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells; the major bioactive hormone is glucagon cleaved by PCSK2/
FunctionGLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues; independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH; TSH; CRH; oxytocin; and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferaton
Length180
Molecular Weight20954
NameGlucagon-like peptide 1
SequenceHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Sequence map37 (92-128)
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA