Detailed description page of Hmrbase2

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11091 details
Primary information
ID11091
Uniprot IDP05110
DescriptionGlucagon precursor [Cleaved into- - Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
OrganismCavia porcellus
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the glucagon family.
Tissue SpecificityNA
Post Translational ModificationProglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells; the major bioactive hormone is glucagon cleaved by PCSK2/
FunctionGLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine; concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract; from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis; enhancing nutrient assimilation through enhanced gastrointestinal function; as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability
Length180
Molecular Weight20972
NameGlucagon-like peptide 2
SequenceHADGSFSDEMNTILDNLATRDFINWLIQTKITD
Sequence map33 (146-178)
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA