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11059 details
Primary information
ID11059
Uniprot IDP62328
DescriptionThymosin beta-4 (T beta 4) (Fx) [Cleaved into- - Hematopoietic systemregulatory peptide (Seraspenide)].
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationCytoplasm
Developmental StageNA
SimilarityBelongs to the thymosin beta family.
Tissue SpecificityExpressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells
Post Translational ModificationNA
FunctionPlays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Length44
Molecular Weight5053
NameThymosin beta-4
SequenceSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Sequence map43 (2-44)
PDB ID1UY5
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA