Detailed description page of Hmrbase2

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10969 details
Primary information
ID10969
Uniprot IDP01194
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Cleaved into- - NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-
OrganismRattus norvegicus
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular LocationNA
Developmental StageNA
SimilarityBelongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post Translational ModificationSpecific enzymatic cleavages at paired basic residues yield the different active peptides.
FunctionMSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
Length235
Molecular Weight26540
NameMelanotropin alpha (Alpha-MSH)
SequenceSYSMEHFRWGKPV
Sequence map13 (124-136)
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA