| Primary information |
|---|
| ID | 10368 |
| Uniprot ID | Q9UBU3 |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Cleaved into- - Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]. |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy |
| Post Translational Modification | O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. |
| Function | Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect; induces adiposity and stimulates gastric acid secretion. Involved in growth regulation |
| Length | 117 |
| Molecular Weight | 12911 |
| Name | Ghrelin-27 |
| Sequence | GSSFLSPEHQRVQQRKESKKPPAKLQP |
| Sequence map | 27 (24-50) |
| PDB ID | 1P7X |
| Drugpedia | NA |
| Receptor | Q92847; Q92847-1;Q02643 |
| Domain | NA |
| Pharmaceutical Use | NA
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