Primary information |
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ID | 10367 |
Uniprot ID | Q9UBU3 |
Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Cleaved into- - Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]. |
Organism | Homo sapiens |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the motilin family. |
Tissue Specificity | Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy |
Post Translational Modification | O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. |
Function | Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect; induces adiposity and stimulates gastric acid secretion. Involved in growth regulation |
Length | 117 |
Molecular Weight | 12911 |
Name | Ghrelin-28 |
Sequence | GSSFLSPEHQRVQQRKESKKPPAKLQPR |
Sequence map | 28 (24-51) |
PDB ID | 1P7X |
Drugpedia | NA |
Receptor | Q92847; Q92847-1;Q02643 |
Domain | NA |
Pharmaceutical Use | NA
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