| Primary information |
|---|
| ID | 10364 |
| Uniprot ID | Q9QYH7 |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Cleaved into- - Ghrelin; Obestatin-23; Obestatin-13]. |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | Ghrelin is broadly expressed with higher expression in the stomach. Very low levels are detected in the hypothalamus; heart; lung; pancreas; intestine and adipose tissue. Obestatin is most highly expr |
| Post Translational Modification | O-n-octanoylation is essential for ghrelin activity. The replacement of Ser-26 by aromatic tryptophan preserves ghrelin activity. Amidation of Leu-98 is essential for obestatin activity. |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility. |
| Length | 117 |
| Molecular Weight | 13176 |
| Name | Obestatin-23 |
| Sequence | FNAPFDVGIKLSGAQYQQHGRAL |
| Sequence map | 23 (76-98) |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | O08725 |
| Domain | NA |
| Pharmaceutical Use | NA
|