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10348 details
Primary information
ID10348
Uniprot IDQ9BDJ6
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Cleaved into- - Ghrelin; Obestatin].
OrganismBos taurus
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the motilin family.
Tissue SpecificityNA
Post Translational ModificationO-n-octanoylation is essential for ghrelin activity. Amidation of Leu-97 is essential for obestatin activity.
FunctionObestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility
Length116
Molecular Weight12793
NameObestatin
SequenceFNAPFNIGIKLAGAQSLQHGQTL
Sequence map23 (75-97)
PDB IDNA
DrugpediaNA
ReceptorQ9BDH9;Q9N1F8;Q9TUJ0;Q9TUJ1
DomainNA
Pharmaceutical UseNA